A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones☆
نویسندگان
چکیده
Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones.
منابع مشابه
Bromomaleimides: new reagents for the selective and reversible modification of cysteine.
Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.
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